Santa Ana is located along a junction between Mexico highway 15 and Mexico highway 2 in northern Sonora, approximately 62 miles south of Nogales, 104 miles north of the state capitol of Hermosillo, and 62 miles east of Caborca.

If you drive north on highway 15 from Santa Ana, you will arrive at the U.S. border at Nogales, Sonora.

Driving south from Santa Ana on highway 15, you will arrive in the Sonora state capital of Hermosillo.

And if you drive west on highway 2 from Santa Ana, you will drive on a well-maintained toll road to Altar, Caborca and points west.

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